Jeremiah Farelli

Jeremiah Farelli

Research Associate

jfarelli@bu.edu


Wendy Iskenderian-Epps

Wendy Iskenderian-Epps

Post-doctoral Faculty Fellow

wepps@bu.edu


Bill Lu

Bill Lu

Research Associate

billzblu@gmail.com


The haloalkanoic acid dehalogenase superfamily(HADSF) consists of more than 13,000 members (growing) in organisms rangingfrom prokaryotes to humans and the vast majority of known catalytic activities carried out by family members are directed at phosphoryl transfer. Identification of the structural features of the HAD members that underlie substrate specificity is a key to the assignment of function in this superfamily and a major goal of my work.

Rui Wu

Rui Wu

Research Associate

RuiWu@bu.edu

I mainly work on X-ray crystal structure determination of several hotdog thioesterases, which play crucial roles in cellular processes like antibiotic/ Fe-S cluster biosynthesis in E. Coli and other pathogenic strains. With the three dimensional structure of the enzyme, especially the liganded structure, we can investigate several interesting points, such as ligand accommodation and relative location of the strictly conserved “catalytic carboxylate” with the ligand in the active site. The relationship between the “hotdog fold” structure and the mechanism of thioesterase substrate recognition and catalysis can help us further define the chemical and biological function in its host cells.